Reduced Peptide Bond Pseudopeptide Analogues of Substance P
نویسندگان
چکیده
منابع مشابه
Reduced peptide bond pseudopeptide analogues of secretin. A new class of secretin receptor antagonists.
The ability to assess the importance of secretin in various physiological processes is limited by the lack of specific potent antagonists. Recently, reduced peptide bond (psi) analogues of bombesin or substance P in which the -CONH- bond is replaced by -CH2NH- are reported to be receptor antagonists. To attempt to develop a new class of secretin receptor antagonists, we have adopted a similar s...
متن کاملImmunological characterization of two substance-P antisera with substance-P fragments and analogues [proceedings].
on the response of bone alkaline phosphatase to parathyrin. The results of a typical experiment showing percentage change in alkaline phosphatase activity compared with the hormone-free control are presented in Fig. 2(b). Tissue from 1-day-old animals was unresponsive to parathyrin, that from the 3-day-old animal showed decreased alkaline phosphatase activity and those from 5and 6-day-old anima...
متن کاملCalcitonin gene-related peptide and substance P contribute to reduced blood pressure in sympathectomized rats.
CGRP and substance P (SP) are produced in dorsal root ganglia (DRG) sensory neurons and modulate vascular tone. Sympathetic and sensory nerves compete for NGF, a potent stimulator of CGRP and SP, and it has been suggested that sympathetic hyperinnervation in spontaneously hypertensive rats may reduce the availability of NGF to sensory nerves, thus reducing CGRP and SP. The purpose of this study...
متن کاملرابطه میان غلظت Substance P و Calcitonin Gene Related Peptide با لثه نواحی مختلف دندانی
زمینه و هدف: در مورد علت درگیری بعضی نواحی خاص لثه (نواحی دندان های 1 بالا و6 بالا و پایین) در برخی بیماری های پریودنتال، هیچ توجیه قابل توجهی عنوان نشده است. با توجه به این که مناطق یاد شده نزدیک فورامن های محل گذر اعصاب قرار دارند و با توجه به این که نوروپپتیدها که از انتهای اعصاب آزاد می شوند، نقش مهمی در برانگیختن التهاب دارند، همچنین از آنجایی که به نقش SP و CGRP در بیماری های پریودنتال اش...
متن کاملSubstance P and the neurokinins: novel peptide neurotransmitters in psychopharmacology.
A new neurotransmitter system is a family of 3 related peptides known as neurokinins. The best known of these is substance P. The others are known simply as neurokinin A and neurokinin B. The specific receptor subtypes that correspond to these 3 neurokinins are neurokinin 1 receptors for substance P, neurokinin 2 receptors for neurokinin A, and neurokinin 3 receptors for neurokinin B. These neu...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)84757-9